Two-Day Comprehensive Workshop on Computer-Aided Drug Designing & RNA-seq-Driven Target Discovery
Aim
The aim of this two-day comprehensive workshop is to provide participants with a thorough understanding and practical insights into two complementary pillars of modern drug discovery: computer-aided drug design (CADD) and RNA-seq-based biomarker and target discovery. Day 1 equips participants with the principles and hands-on techniques of molecular docking, ligand optimization, protein modelling, and molecular dynamics. Day 2 builds the upstream layer- how to go from raw RNA-seq reads to differentially expressed genes, enriched pathways, and validated candidate drug targets that can be taken forward into structure-based design. Together, the two days deliver a complete "sequence → target → molecule" workflow.
Duration: 2 Days
Location/mode: Online
Target Participants
The target participants are individuals interested in gaining in-depth knowledge and practical skills in drug discovery and bioinformatics. This workshop is suitable for:
ü Researchers and scientists in pharmaceuticals, medicinal chemistry, and related disciplines
ü Graduate students and Ph.D. scholars in life sciences, biotechnology, and bioinformatics
ü Academicians and faculty teaching molecular biology, genomics, or drug design
ü Industry professionals exploring target discovery and structure-based design pipelines
No prior programming experience is required.
Important Dates & Time
The workshop will be held on January 30–31, 2027, from 5:00 PM to 6:30 PM IST, followed by a 15-minute break, and will resume from 6:45 PM to 8:00 PM IST each day. The total duration will be 2 hours and 45 minutes per day, including the break, and may be extended slightly if required. The last date for registration is January 28, 2027, at 6:00 PM IST.
Registration
Interested participants may visit www.negenome.in or use the registration link: https://forms.gle/6ahKSUa391VQcT3g6
Fee Plan
The registration fee is INR 1,050/- for Students, INR 1,250/- for Ph.D. Scholars / Researchers, INR 1,550/- for Academicians / Faculty, and INR 2,000/- for Industry Professionals.
10% Discount if you register before 31 December, 2026. Hurry up!
Workshop Outline
Day 1: Computer-Aided Drug Designing
ü Overview of Molecular Docking
ü Applications in Drug Discovery and Bioinformatics
ü Case studies highlighting successful applications
ü Understanding UniProt and PDB databases
ü Retrieving biological and structural information
ü Practical exercises on data retrieval and interpretation
ü Importance of Ligand Optimization
ü Techniques for Ligand Optimization
ü Identifying and Analyzing Binding Sites and Pockets
ü Hands-on exercises using relevant tools
ü Introduction to Protein Modeling
ü Homology Modeling and Ab Initio Modeling
ü Tools and Software for Protein Modeling
ü Practical exercises in creating protein models
ü Practical session on performing molecular docking
ü Using available software for docking simulations
ü Analyzing and interpreting docking results
ü Understanding Binding Energy
ü Analyzing Protein–Ligand Interactions
ü Introduction to Molecular Dynamics
ü Visualization of Molecular Dynamics simulations
ü Hands-on activities on analyzing binding energy and interactions
ü Overview of GeneCard and its significance
ü Integrating molecular docking results with GeneCard data
ü Case studies demonstrating successful integration
ü Q&A
Day 2: RNA-seq to Biomarker & Target Discovery
ü Introduction to RNA-seq
ü What RNA-seq measures and why it matters for drug discovery
ü Common applications: biomarker discovery, target identification, mechanism-of-action studies
ü Quality Control of Raw Reads
ü Understanding FASTQ format and quality scores
ü Hands-on: running FastQC and interpreting reports
ü Read trimming and filtering with fastp
ü Read Alignment and Quantification
ü Reference genomes and annotation files (GTF/GFF)
ü Aligning reads with HISAT2 / STAR (conceptual + demo)
ü Generating count matrices (featureCounts / HTSeq)
ü Differential Expression Analysis with DESeq2
ü Experimental design and normalization concepts
ü Hands-on: running DESeq2 on a small demo dataset
ü Interpreting log fold change, p-values, and adjusted p-values
ü Visualizing results: volcano plots, MA plots, heatmaps
ü Pathway and Functional Enrichment
ü Hands-on: enrichment using clusterProfiler / Enrichr
ü Interpreting enriched pathways in a disease or drug-response context
ü From DEGs to Candidate Drug Targets
ü Filtering and prioritizing differentially expressed genes
ü Cross-referencing with druggability databases (DGIdb, Open Targets)
ü Shortlisting candidate targets for structure-based design
ü Bridge Session: Linking RNA-seq to CADD
ü How Day 2 outputs feed directly into Day 1 workflows
ü From candidate target → protein structure retrieval (PDB/UniProt) → docking
ü End-to-end case study: RNA-seq hit → target validation → molecular docking
ü Q&A
Prerequisites
· A computer system with a stable internet connection is necessary.
· No prior programming experience or specialized prerequisites are necessary to attend this workshop.
· Basic familiarity with molecular biology is helpful but not mandatory.
· Participants are encouraged (but not required) to attend both days for the full sequence-to-structure experience.
Deliverables
v E-certificates will be issued to all participants within 5 working days of the workshop's conclusion.
v Access to recorded sessions for future reference and review.
v Hands-on demo datasets and command/script files used during the sessions.
v A curated resource list (tools, databases, and further-reading links) for both CADD and RNA-seq analysis.
Contact
If you have any questions or need further information, please don't hesitate to contact us at negenome@gmail.com/8135038866
We look forward to having you at the Two Days Comprehensive Workshop on Computer-Aided Drug Designing & RNA-seq-Driven Target Discovery.
Registration
Interested participants can register using the link provided below.
Negenome Bio Solutions Pvt. Ltd.
📍 Corporate Office
Shernagar, Agomani, Dhubri, Assam – 783335, India
📍 Jammu Branch Office
House No. 45, Sector 3, Trikuta Nagar, Jammu, Tawi – 180012, India
📧 Email: negenome@gmail.com
📞 Phone/WhatsApp: +91 8135038866